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Peptides, glycoconjugués et métaux en biologie

4 Micro-organismes et physiopathologie intestinale


Equipe 4 :  Micro-organismes et physiopathologie intestinale  ERL U1057 INSERM

Directeur de l’unité :Germain TRUGNAN (PUPH1)



La thématique centrale de l’équipe se concentre sur les modalités et les conséquences du dialogue entre microorganismes et cellules épithéliales intestinales humaines. Nous développons une démarche intégrative et translationnelle allant de la biologie fondamentale à la clinique humaine. Nous disposons pour cela d’un large éventail d’expertises reconnues que nous mettons au service d’un projet resserré : biologie cellulaire, imagerie cellulaire, lipidomique et biophysique des membranes, protéomique, physiopathologie digestive, microbiologie, virologie cellulaire et moléculaire, gastroentérologie clinique.
Deux aspects particuliers de ce dialogue ont été choisis pour leurs intérêts fondamentaux et leurs retombées cliniques potentielles. Nous nous intéressons d’une part à des microorganismes non pathogènes, les bactéries du microbiote intestinal, aux mécanismes de leur dialogue avec les cellules épithéliales intestinales et aux conséquences d’une dysbiose dans le contexte des maladies inflammatoires chroniques de l’intestin (MICI). Nous nous intéressons d’autre part à des microorganismes pathogènes, les rotavirus, au rôle joué par l’épithélium intestinal dans leur assemblage et leur propagation et surtout aux applications de ces connaissances pour le développement de stratégies thérapeutiques antivirales innovantes. Ces deux axes sont intriqués et s’appuient sur la nécessité commune de disposer de connaissances et d’outils performants pour la biologie cellulaire, la biochimie et la biophysique des cellules épithéliales intestinales.
L’évolution des travaux menés depuis plusieurs années  nous ont conduits à développer des recherches interdisciplinaires aux interfaces entre la chimie, la physique, la biologie et la médecine. Nous avons notamment engagé des collaborations approfondies avec l’UMR 7203 que nous avons rejoint dernièrement après une évaluation A+ de l’AERES pour développer des projets interdisciplinaires

  1. Thématique : procaryotes et inflammation intestinale

  2. Thématique : Interaction virus - cellules intestinales


    Publications et contrats

    ANR MI2  2010 IMPRO-Fprau : Mécanismes Intégrés de l'Inflammation  : Analyse des effets immuno-modulateurs des peptides issus d'une protéine spécifique de Faecalibacterium prausnitzii,  une bactérie commensale impliquée dans la maladie de Crohn

    Publications


    2012

    Inflammatory bowel disease therapies and cancer risk where are we and where are we going?

    Beaugerie L.

    Gut.

    2012 Jan 12.

    2012

    Development of the first disability index for inflammatory bowel disease based on the international classification of functioning, disability and health.

    Peyrin-Biroulet L, Cieza A, Sandborn WJ, Coenen M, Chowers Y, Hibi T, Kostanjsek N, Stucki G, Colombel JF; International Programme to Develop New Indexes for Crohn's Disease (IPNIC) group.

    Gut.

    2012 Feb;61(2) 241-7.

    2012

    High plasma level of nucleocapsid-free envelope glycoprotein-positive lipoproteins in hepatitis C patients.

    Scholtes C, Ramiere C, Rainteau D, Perrin-Cocon L, Wolf C, Humbert L, Carreras M, Guironnet-Paquet A, Zoulim F, Bartenschlager R, Lotteau V, André P, Diaz O.

    Hepatology.

    2012 Jan 30.. 10.1002/hep.25628

    2012

    Excess primary intestinal lymphoproliferative disorders in patients with inflammatory bowel disease.

    Sokol H, Beaugerie L, Maynadié M, Laharie D, Dupas JL, Flourié B, Lerebours E, Peyrin-Biroulet L, Allez M, Simon T, Carrat F, Brousse N; for the CESAME Study Group.

    Inflamm Bowel Dis.

    2012 Jan 23. doi. 10.1002/ibd.22889

    2012

    Colorectal neoplasia in PSC-IBD patients are times changing?

    Sokol H, Chazouilleres O.

    Liver Int

    2012 Feb;32(2) 175-6. doi 10.1111/j.1478-3231.

    2011.02671.x.

    2012

    Glycan-modifying bacteria-derived soluble factors from Bacteroides thetaiotaomicron and Lactobacillus casei inhibit rotavirus infection in human intestinal cells.

    Varyukhina S, Freitas M, Bardin S, Robillard E, Tavan E, Sapin C, Grill JP, Trugnan G.

    Microbes Infect.

    2012 Mar;14(3) 273-8.

    2011

    Diagnostic Profiles Determined by the c.a.r.t Procedure ibd Patients and Fatigue.

    Banovic I, Gilibert D, Jebrane A, Cosnes J.

    J Health Psychol

    2011

    2011

    Air mass pushing the liver.,

    Barret M., Coriat R., Beaugerie L., Sokol H.,

    Digestive and Liver Disease ,

    2011 Dec;43(12) 1025.

    2011

    Pregnancy outcome in patients with inflammatory bowel disease treated with thiopurines: cohort from the CESAME Study.,

    Coelho J., Beaugerie L., Colombel J. F., Hébuterne X., Lerebours E., Lémann M., Baumer P., Cosnes J., Bourreille A., Gendre J. P., Seksik P., Blain A., Metman E. H., Nisard A., Cadiot G., Veyrac M., Coffin B., Dray X., Carrat F., Marteau P.,,

    Gut ,

    2011, 60 2 198-203

    2011

    [Complications of celiac disease.].

    Cosnes J, Nion-Larmurier I.

    Pathol Biol (Paris).

    2011 May 26.

    2011

    Epidemiology and natural history of inflammatory bowel diseases.,

    Cosnes J., Gower-Rousseau C., Seksik P., Cortot A.,

    Gastroenterology ,

    2011, 140 6 1785-94

    2011

    Trade-off between bile resistance and nutritional competence drives Escherichia coli diversification in the mouse gut.

    De Paepe M, Gaboriau-Routhiau V, Rainteau D, Rakotobe S, Taddei F, Cerf-Bensussan N.

    PLoS Genet.

    2011 Jun;7(6) e1002107.

    2011

    Immediate neuroendocrine signaling after partial hepatectomy through acute portal hyperpressure and cholestasis.

    Doignon I, Julien B, Serriere-Lanneau V, Garcin I, Alonso G, Nicou A, Monnet F, Gigou M, Humbert L, Rainteau D, Azoulay D, Castaing D, Gillon MC, Samuel D, Duclos-Vallée JC, Tordjmann T.

    J Hepatol.

    2011 Mar;54(3) 481-8.

    2011

    C-reactive protein and transesophageal echocardiographic markers of thromboembolism in patients with atrial fibrillation.,

    Ederhy S., Di Angelantonio E., Dufaitre G., Meuleman C., Masliah J., Boyer-Chatenet L., Boccara F., Cohen A.,

    Int J Cardiol.

    2011 Mar 12.

    2011

    Proof of principle for transfusion of in vitro-generated red blood cells.

    Giarratana MC, Rouard H, Dumont A, Kiger L, Safeukui I, Le Pennec PY, François S, Trugnan G, Peyrard T, Marie T, Jolly S, Hebert N, Mazurier C, Mario N, Harmand L, Lapillonne H, Devaux JY, Douay L.

    Blood.

    2011 Nov 10;118(19) 5071-9.

    2011

    A comparison of small monetary incentives to convert survey non-respondents a randomized control trial.

    Griffin JM, Simon AB, Hulbert E, Stevenson J, Grill JP, Noorbaloochi S, Partin MR.

    BMC Med Res Methodol.

    2011 May 26;11 PAGE ?

    2011

    Regulation of colon cancer cell proliferation and migration by MD-2 activity.

    Grondin V, Seksik P, Dumont S, Thomas G, Trugnan G, Fléjou JF, Masliah J, Wendum D, Bachelet M.

    Innate Immun.

    2011 Aug;17(4) 414-22.

    2011

    Successive treatment with cyclosporine and infliximab in steroid-refractory ulcerative colitis.,

    Leblanc S., Allez M., Seksik P., Flourié B., Peeters H., Dupas J.L., Bouguen G., Peyrin-Biroulet L., Duclos B., Bourreille A., Dewit O., Bouhnik Y., Michetti P., Chaussade S., Saussure P., Mary J.Y., Colombel J.F., Lémann M.,,

    Am J Gastroenterol.,

    2011, 106 4 771-7

    2011

    Mononeuropathy multiplex associated with acute parvovirus B19 infection: characteristics, treatment and outcome.,

    Lenglet T., Haroche J., Schnuriger A., Maisonobe T., Viala K., Michel Y., Chelbi F., Grabli D., Seror P., Garbarg-Chenon A., Amoura Z., Bouche P.,

    J Neurology ,

    2011, 258 7 1321-6

    2011

    Protoporphyrin retention in hepatocytes and Kupffer cells prevents sclerosing cholangitis in erythropoietic protoporphyria mouse model.

    Lyoumi S, Abitbol M, Rainteau D, Karim Z, Bernex F, Oustric V, Millot S, Lettéron P, Heming N, Guillmot L, Montagutelli X, Berdeaux G, Gouya L, Poupon R, Deybach JC, Beaumont C, Puy H.

    Gastroenterology.

    2011 Oct;141(4) 1509-19, 1519.e1-3.

    2011

    [Chronic diarrhea which diagnostic approach?].

    Nion-Larmurier I, Cosnes J.

    Rev Prat.

    2011 Nov;61(9) 1278.

    2011

    Monitoring epidemic viral respiratory infections using one-step real-time triplex RT-PCR targeting influenza A and B viruses and respiratory syncytial virus.

    Papillard-Marechal S, Enouf V, Schnuriger A, Vabret A, Macheras E, Rameix-Welti MA, Page B, Freymuth F, van der Werf S, Garbarg-Chenon A, Chevallier B, Gaillard JL, Gault E.

    J Med Virol.

    2011 Apr;83(4) 695-701. doi 10.1002/jmv.22006.

    2011

    [Impact of Rotavirus gastroenteritis requiring hospitalization or presenting to emergency room among children less than 5years in France.].

    Parez N, Mory O, Pozzetto B, Garbag-Chenon A, Pillet S, Texier N, Téhard B.

    Pathol Biol (Paris).

    2011 Jul 30.

    2011

    Development of the Crohn's disease digestive damage score, the Lémann score.,

    Pariente B., Cosnes J., Danese S., Sandborn W. J., Lewin M., Fletcher J. G., Chowers Y., D'Haens G., Feagan B. G., Hibi T., Hommes D. W., Irvine E. J., Kamm M. A., Loftus E. V., Louis E., Michetti P., Munkholm P., Oresland T., Panés J., Peyrin-Biroulet L., Reinisch W., Sands B. E., Schoelmerich J., Schreiber S., Tilg H., Travis S., Van Assche G., Vecchi M., Mary J.-Y., Colombel J.-F., Lémann M.,

    Inflamm Bowel Dis

    2011, 17 6 1415-22

    2011

    Increased Risk for Nonmelanoma Skin Cancers in Patients Who Receive Thiopurines for Inflammatory Bowel Disease.,

    Peyrin-Biroulet L., Khosrotehrani K., Carrat F., Bouvier A.-M., Chevaux J.-B., Simon T., Carbonnel F., Colombel J.-F., Dupas J.-L., Godeberge P., Hugot J.-P., Lémann M., Nahon S., Sabaté J.-M., Tucat G., Beaugerie L.,,

    Gastroenterology ,

    2011 Nov;141(5):1621-2

    2011

    Anti-inflammatory properties of dairy lactobacilli.

    Santos Rocha C, Lakhdari O, Blottiere HM, Blugeon S, Sokol H, Bermu'dez-Humara'n LG, Azevedo V, Miyoshi A, Doré J, Langella P, Maguin E, van de Guchte M.

    Inflamm Bowel Dis.

    2011 Aug 11. doi 10.1002/ibd.21834.

    2011

    *page Anti-inflammatory properties of dairy lactobacilli.,

    Santos Rocha C., Lakhdari O., Blottière H. M., Blugeon S., Sokol H., Bermu'Dez-Humara'N L. G., Azevedo V., Miyoshi A., Doré J., Langella P., Maguin E., Van De Guchte M.,

    Inflamm Bowel Dis,

    2011 Aug 11. doi: 10.1002/ibd.21834

    2011

    Incidence of nodular regenerative hyperplasia in inflammatory bowel disease patients treated with azathioprine.,

    Seksik P., Mary J.-Y., Beaugerie L., Lémann M., Colombel J.-F., Vernier-Massouille G., Cosnes J.,,

    Inflamm Bowel Dis

    2011, 17 2 565-72

    2011

    Limits of sequencing and phylogenetic analysis to assess B19V transmission by single-donor blood component.,

    Servant-Delmas A., Laperche S., Mercier M., Michel Y., Garbarg-Chenon A., Boyeldieu D., Pelissier E., Lefrère J.-J.,,

    Vox sanguinis

    2011, 100 2 254-5

    2011

    Arsenic trioxide reduces 2,4,6-trinitrobenzene sulfonic acid-induced murine colitis via nuclear factor-{ kappa} B down-regulation and caspase-3 activation.,

    Singer M., Trugnan G., Chelbi-Alix M. K.,

    Innate Immun ,

    2011 Aug;17(4) 365-74.

    2011

    Rotavirus rearranged genomic RNA segments are preferentially packaged into viruses despite not conferring selective growth advantage to viruses.

    Troupin C, Schnuriger A, Duponchel S, Deback C, Schnepf N, Dehee A, Garbarg-Chenon A.

    PLoS One.

    2011; 6(5) e20080.

    2011

    Food-starch granulomatous peritonitis in a patient with ileal Crohn's disease a rare aetiology of peritoneal giant cell granulomas with caseation necrosis mimicking peritoneal tuberculosis.

    Varinot J, Cosnes J, Chafai N, Bennis M, Fléjou JF, Svrcek M.

    Int J Colorectal Dis.

    2011 Oct 18.

    2011

    Low prevalence of colonoscopic surveillance of inflammatory bowel disease patients with longstanding extensive colitis: a clinical practice survey nested in the CESAME cohort.,

    Vienne A., Simon T., Cosnes J., Baudry C., Bouhnik Y., Soulé J.C., Chaussade S., Marteau P., Jian R., Delchier J.-C., Coffin B., Admane H., Carrat F., Drouet E., Beaugerie L.,

    Alimentary Pharmacology 

    and Therapeutics ,

    2011, 34 2 188-95

    2010

    Lipid domain separation, bilayer thickening and pearling induced by the cell penetrating peptide penetratin.,

    Lamazière A., Maniti O., Wolf C., Lambert O., Chassaing G., Trugnan G., Ayala-Sanmartin J.,

    BBA - Biochimica et Biophysica Acta

    2010, 1798 (12) 2223-30

    2010

    Distinct behaviour of the homeodomain derived cell penetrating peptide penetratin in interaction with different phospholipids.,

    Maniti O., Alves I., Trugnan G., Ayala-Sanmartin J.,

    PLoS ONE ,

    2010, 5 (12) e15819

    2010

    [Impact of childhood immunization programs in 20th century France].

    Ajana F, Alain S, Angelin-Duclos C, Aumaitre H, Bregere P, Launay O, Parez N, Rogeaux O, Soubeyrand B, Strady C, Weil-Olivier C. Group Avancées Vaccinales, Gaillat J.

    Rev Prat.

    2010 Oct 20;60(8) 1044-8.

    2010

    Crohn's disease and fatigue: constancy and co-variations of activity of the disease, depression, anxiety and subjective quality of life.,

    Banovic I., Gilibert D., Cosnes J.,,

    Psychology, Health & Medicine

    2010, 15 4 394-405

    2010

    Liver dysfunction in patients with IBD under immunosuppressive treatment: do we need to fear?,

    Beaugerie L., Gerbes A. L.,

    Gut ,

    2010, 59 10 1310-1

    2010

    Appendicitis, not appendectomy, is protective against ulcerative colitis, both in the general population and first-degree relatives of patients with IBD.,

    Beaugerie L., Sokol H.,

    Inflamm Bowel Dis

    2010, 16 2 356-7

    2010

    Risk factors for neoplasia in inflammatory bowel disease patients with pancolitis.,

    Bergeron V., Vienne A., Sokol H., Seksik P., Nion-Larmurier I., Ruskone-Fourmestraux A., Svrcek M., Beaugerie L., Cosnes J.,

    Am J Gastroenterol.

    2010, 105 11 2405-11

    2010

    Rotaviruses associate with cellular lipid droplet components to replicate in viroplasms, and compounds disrupting or blocking lipid droplets inhibit viroplasm formation and viral replication.,

    Cheung W., Gill M., Esposito A., Kaminski C. F., Courousse N., Chwetzoff S., Trugnan G., Keshavan N., Lever A., Desselberger U.,

    J Virol ,

    2010, 84 13 6782-98

    2010

    Acute cryptosporidiosis as a cause of sudden recurrence of digestive symptoms in patients with Crohn's disease.,

    Colussi O., Rouen A., Seksik P., Cosnes J., Beaugerie L., Sokol H.,

    J Crohns Colitis ,

    2010, 4 6 669-70

    2010

    Rotavirus-like particles a novel nanocarrier for the gut.

    Cortes-Perez NG, Sapin C, Jaffrelo L, Daou S, Grill JP, Langella P, Seksik P, Beaugerie L, Chwetzoff S, Trugnan G.

    J Biomed Biotechnol.

    2010; 2010:317545

    2010

    Smoking, physical activity, nutrition and lifestyle: environmental factors and their impact on IBD.,

    Cosnes J.,

    Digestive Diseases

    2010, 28 3 411-7

    2010

    Human intestinal microbiota gene risk factors for antibiotic-associated diarrhea: perspectives for prevention. Risk factors for antibiotic-associated diarrhea.,

    De La Cochetière M. F., Montassier E., Hardouin J.-B., Carton T., Le Vacon F., Durand T., Lalande V., Petit J.-C., Potel G., Beaugerie L.,

    Microb Ecol.,

    2010, 59 4 830-7

    2010

    Characteristics and clinical course of primary sclerosing cholangitis in France a prospective cohort study.

    Garioud A, Seksik P, Chrétien Y, Corphechot C, Poupon R, Poupon RE, Chazouilleres O.

    Eur J Gastroenterol Hepatol.

    2010 Jul;22(7) 842-7.

    2010

    Unilateral carotid granulomatous arteritis and Crohn's disease.,

    Gobron C., Kaci R., Sokol H., Vahedi K., Lejoyeux P., Guillaud C., Wechsler B., Gray F., Bousser M.-G.,,

    Revue neurologique

    2010, 166 5 542-6

    2010

    Surveillance to estimate the burden of rotavirus gastroenteritis in children aged less than 3 years attending day care centers in Paris, France.,

    Grimprel E., Garbarg-Chenon A., PirÁon J.-Y., Curran D., Soriano-GabarrÛ M., Meyer N.,

    Human Vaccines ,

    2010, 6 5 399-406

    2010

    Regulation of colon cancer cell proliferation and migration by MD-2 activity.,

    Grondin V., Seksik P., Dumont S., Thomas G., Trugnan G., Fléjou J.-F., Masliah J., Wendum D., Bachelet M.,

    Innate Immun ,

    2010, epub ahead of print *page

    2010

    The enteropathy associated with common variable immunodeficiency: the delineated frontiers with celiac disease.,

    Malamut G., Verkarre V., Suarez F., Viallard J.-F., Lascaux A.-S., Cosnes J., Bouhnik Y., Lambotte O., Béchade D., Ziol M., Lavergne A., Hermine O., Cerf-Bensussan N., Cellier C.,

    Am J Gastroenterol.,

    2010, 105 10 2262-75

    2010

    Natural history of Crohn's disease: comparison between childhood- and adult-onset disease.,

    Pigneur B., Seksik P., Viola S., Viala J., Beaugerie L., Girardet J.-P., Ruemmele F. M., Cosnes J.,

    Inflamm Bowel Dis,

    2010, 16 6 953-61

    2010

    Severe skin lesions cause patients with inflammatory bowel disease to discontinue anti-tumor necrosis factor therapy.,

    Rahier J.-F., Buche S., Peyrin-Biroulet L., Bouhnik Y., Duclos B., Louis E., Papay P., Allez M., Cosnes J., Cortot A., Laharie D., Reimund J.-M., Lémann M., Delaporte E., Colombel J.-F.,,

    Clinical Gastroenterology and Hepatology ,

    2010, 8 12 1048-55

    2010

    [Gut microbiota and IBD].,

    Seksik P.,

    Gastroenterol Clin Biol.

    2010, 34 Suppl 1 S44-51

    2010

    Sera from patients with Crohn's disease break bacterial lipopolysaccharide tolerance of human intestinal epithelial cells via MD-2 activity.,

    Seksik P., Sokol H., Grondin V., Adrie C., Duboc H., Pigneur B., Thomas G., Beaugerie L., Trugnan G., Masliah J., Bachelet M.,,

    Innate Immun

    2010, 16 6 381-90

    2010

    Current smoking, not duration of remission, delays Crohn's disease relapse following azathioprine withdrawal.

    Sokol H, Seksik P, Nion-Larmurier I, Vienne A, Beaugerie L, Cosnes J.

    Inflamm Bowel Dis.

    2010 Mar;16(3) 362-3.

    2010

    Misleading statement in trial on false-positive results in lung cancer screening.,

    Sokol H. N.,

    Annals of internal medicine ,

    2010, 153 3 210; author reply 210

    2010

    Body mass index and disease activity at treatment initiation: potential new predictors of response to azathioprine therapy in IBD.,

    Sokol H., Beaugerie L.,

    Inflamm Bowel Dis

    2010, 16 4 714-5

    2010

    [Acute diarrhea in the adult].,

    Sokol H., Beaugerie L.,

    Rev pra

    2010, 60 3 413-8

    2010

    Gastrointestinal involvement and manifestations in systemic mastocytosis.,

    Sokol H., Georgin-Lavialle S., Grandpeix-Guyodo C., Canioni D., Barete S., Dubreuil P., Lortholary O., Beaugerie L., Hermine O.,

    Inflamm Bowel Dis

    2010, 16 7 1247-53

    2010

    The intestinal microbiota in inflammatory bowel diseases: time to connect with the host.,

    Sokol H., Seksik P.,

    Current Opinion in Gastroenterology ,

    2010, 26 4 327-31

    2010

    Usefulness of co-treatment with immunomodulators in patients with inflammatory bowel disease treated with scheduled infliximab maintenance therapy.,

    Sokol H., Seksik P., Carrat F., Nion-Larmurier I., Vienne A., Beaugerie L., Cosnes J.,

    Gut ,

    2010, 59 10 1363-8

    2010

    Current smoking, not duration of remission, delays Crohn's disease relapse following azathioprine withdrawal.,

    Sokol H., Seksik P., Nion-Larmurier I., Vienne A., Beaugerie L., Cosnes J.,

    Inflamm Bowel Dis

    2010, 16 3 362-3

    2010

    Crypt abscess-associated microbiota in inflammatory bowel disease and acute self-limited colitis.,

    Sokol H., Vasquez N., Hoyeau-Idrissi N., Seksik P., Beaugerie L., Lavergne-Slove A., Pochart P., Marteau P.,

    World J Gastroenterology ,

    2010, 16 5 583-7

    2010

    Methylation tolerance due to an O6-methylguanine DNA methyltransferase (MGMT) field defect in the colonic mucosa: an initiating step in the development of mismatch repair-deficient colorectal cancers.,

    Svrcek M., Buhard O., Colas C., Coulet F., Dumont S., Massaoudi I., Lamri A., Hamelin R., Cosnes J., Oliveira C., Seruca R., Gaub M.-P., Legrain M., Collura A., Lascols O., Tiret E., Fléjou J.-F., Duval A.,

    Gut ,

    2010, 59 11 1516-26

    2010

    Rearranged genomic RNA segments offer a new approach to the reverse genetics of rotaviruses.,

    Troupin C., Dehée A., Schnuriger A., Vende P., Poncet D., Garbarg-Chenon A.,

    J Virol ,

    2010, 84 13 6711-9

    2010

    The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Definitions and diagnosis.,

    Van Assche G., Dignass A., Panes J., Beaugerie L., Karagiannis J., Allez M., Ochsenk¸hn T., Orchard T., Rogler G., Louis E., Kupcinskas L., Mantzaris J. G., Travis S., Stange E.,,

    J Crohns Colitis ,

    2010, 4 1 7-27

    2010

    Intragastric administration of a superoxide dismutase-producing recombinant Lactobacillus casei BL23 strain attenuates DSS colitis in mice.,

    Watterlot L., Rochat T., Sokol H., Cherbuy C., Bouloufa I., Lefèvre F., Gratadoux J.-J., Honvo-Hueto E., Chilmonczyk S., Blugeon S., Corthier G., Langella P., Berm˙dez-Humar·n L. G.,

    International J Food Microbiology ,

    2010, 144 1 35-41

    2009

    Lipid reorganization induced by membrane-active peptides probed using differential scanning calorimetry.,

    Joanne P., Galanth C., Goasdoué N., Nicolas P., Sagan S., Lavielle S., Chassaing G., El Amri C., Alves I. D.,

    BBA - Biochimica et Biophysica Acta ,

    2009, 1788 (9): 1772-81

    2009

    Tubular structures in heterogeneous membranes induced by the cell penetrating peptide penetratin.,

    Lamazière A., Chassaing G., Trugnan G., Ayala-Sanmartin J.,

    Commun Integr Biol ,

    2009, 2: (3) 223-4

    2009

    Abnormal transbilayer distribution of phospholipids in red blood cell membranes in schizophrenia.,

    Nuss P., Tessier C., Ferreri F., De Hert M., Peuskens J., Trugnan G., Masliah J., Wolf C.,

    Psychiatry Research

    2009, 169 (2): 91-6

    2009

    Basolateral internalization of GPI-anchored proteins occurs via a clathrin-independent flotillin-dependent pathway in polarized hepatic cells.

    Ait-Slimane T, Galmes R, Trugnan G, Maurice M.

    Mol Biol Cell.

    2009 Sep;20(17) 3792-800.

    2009

    Perception of improved state of health and subjective quality of life in Crohn's disease patients treated with Infliximab.

    Banovic I, Gilibert D, Cosnes J.

    J Crohns Colitis.

    2009 Feb;3(1) 25-31.

    2009

    Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease a prospective observational cohort study.

    Beaugerie L, Brousse N, Bouvier AM, Colombel JF, Lémann M, Cosnes J, Hébuterne X, Cortot A, Bouhnik Y, Gendre JP, Simon T, Maynadié M, Hermine O, Faivre J, Carrat F; CESAME Study Group.

    Lancet.

    2009 Nov 7;374(9701) 1617-25.

    2009

    Patients with drug-induced microscopic colitis should not be included in controlled trials assessing the efficacy of anti-inflammatory drugs in microscopic colitis.

    Beaugerie L, Pardi DS.

    Gastroenterology.

    2009 Oct;137(4) 1535-6.

    2009

    Noncolorectal malignancies in inflammatory bowel disease: more than meets the eye.,

    Beaugerie L., Sokol H., Seksik P

    Digestive Diseases ,

    2009, 27 3 375-81

    2009

    Cyclosporine treatment of steroid-refractory ulcerative colitis during pregnancy.

    Branche J, Cortot A, Bourreille A, Coffin B, de Vos M, de Saussure P, Seksik P, Marteau P, Lemann M, Colombel JF.

    Inflamm Bowel Dis.

    2009 Jul;15(7) 1044-8.

    2009

    Environmental risk factors in Crohn's disease and ulcerative colitis an update.

    Carbonnel F, Jantchou P, Monnet E, Cosnes J.

    Gastroenterol Clin Biol.

    2009 Jun;33 Suppl 3

    2009

    [Inflammatory bowel disease from sulfasalazine to biologics].

    Cosnes J, Seksik P.

    Gastroenterol Clin Biol.

    2009, Aug-Sep;33(8-9) 692-701.

    2009

    [Diagnosis of celiac disease in a young woman].

    Cosnes J.

    Gastroenterol Clin Biol.

    2009, Jun-Jul;33(6-7) 518-20.

    2009

    Can we modulate the clinical course of inflammatory bowel diseases by our current treatment strategies?

    Cosnes J.

    Digestive Diseases ,.

    2009;27(4)516-21.

    2009

    Toll-like receptor 2 is critical for induction of Reg3 beta expression and intestinal clearance of Yersinia pseudotuberculosis.,

    Dessein R., Gironella M., Vignal C., Peyrin-Biroulet L., Sokol H., Secher T., Lacas-Gervais S., Gratadoux J.-J., Lafont F., Dagorn J.-C., Ryffel B., Akira S., Langella P., N˘Òez G., Sirard J.-C., Iovanna J., Simonet M., Chamaillard M.,

    Gut ,

    2009, 58 6 771-6

    2009

    Endpoints for clinical trials evaluating disease modification and structural damage in adults with Crohn's disease.

    D'Haens GR, Fedorak R, Lémann M, Feagan BG, Kamm MA, Cosnes J, Rutgeerts PJ, Marteau P, Travis S, Schoelmerich J, Hanauer S, Sandborn WJ; IOIBD Membership.

    Inflamm Bowel Dis.

    2009 Oct;15(10) 1599-604.

    2009

    Predictive factors of eczema-like eruptions among patients without cutaneous psoriasis receiving infliximab a cohort study of 92 patients.

    Esmailzadeh A, Yousefi P, Farhi D, Bachmeyer C, Cosnes J, Berenbaum F, Duriez P, Aractingi S, Khosrotehrani K.

    Dermatology.

    2009;219(3) 263-7.

    2009

    [Cutaneous manifestations associated with chronic inflammatory bowel disease].

    Farhi D, Cosnes J, Aractingi S, Khosrotehrani K.

    Ann Dermatol Venereol.

    2009 Nov;136(11) 828-33; 826-7, 834-5.

    2009

    Hospital-based surveillance to estimate the burden of rotavirus gastroenteritis among European children younger than 5 years of age.

    Forster J, Guarino A, Parez N, Moraga F, Roman E, Mory O, Tozzi AE, de Aguileta AL, Wahn U, Graham C, Berner R, Ninan T, Barberousse C, Meyer N, Soriano-Gabarró M; and the Rotavirus Study Group.

    Pediatrics.

    2009 Mar;123(3) e393-400.

    2009

    Irritable bowel syndrome is more frequent in patients hospitalized for ischaemic colitis results of a case-control study.

    Hervé S, Beaugerie L, Bouhnik Y, Savoye G, Colombel JF, Dyard F, Hourmand-Ollivier I, Dao T, Vial M, Lerebours E.

    Neurogastroenterol Motil.

    2009 Nov;21(11) 1170-e102.

    2009

    Presentation and long-term follow-up of refractory celiac disease comparison of type I with type II.

    Malamut G, Afchain P, Verkarre V, Lecomte T, Amiot A, Damotte D, Bouhnik Y, Colombel JF, Delchier JC, Allez M, Cosnes J, Lavergne-Slove A, Meresse B, Trinquart L, Macintyre E, Radford-Weiss I, Hermine O, Brousse N, Cerf-Bensussan N, Cellier C.

    Gastroenterology.

    2009 Jan;136(1) 81-90.

    2009

    The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age.,

    Mariat D., Firmesse O., Levenez F., Guimarăes V., Sokol H., Doré J., Corthier G., Furet J.-P.,,

    BMC Microbiology

    2009, 9 123

    2009

    Bacteriotherapy for inflammatory bowel disease therapeutic tool and/or pharmacological vectors?

    Marteau P, Sokol H, Dray X, Seksik P.

    Gastroenterol Clin Biol.

    2009 Jun;33 Suppl 3

    2009

    [Celiac disease].,

    Nion-Larmurier I., Cosnes J.,

    Gastroenterol Clin Biol.

    2009, 33 6-7 508-17

    2009

    Papular-purpuric gloves and socks syndrome associated with B19V infection in a 6-year-old child.,

    Parez N., Dehée A., Michel Y., Veinberg F., Garbarg-Chenon A., J

    Clin Virol ,

    2009, 44 2 167-9

    2009

    Lipidomics of the red cell in diagnosis of human disorders.

    Quinn PJ, Rainteau D, Wolf C.

    Methods Mol Biol.

    2009;579

    2009

    Incidence of benign upper respiratory tract infections, HSV and HPV cutaneous infections in inflammatory bowel disease patients treated with azathioprine.,

    Seksik P., Cosnes J., Sokol H., Nion-Larmurier I., Gendre J.-P., Beaugerie L.,

    Alimentary Pharmacology 

    and Therapeutics ,

    2009, 29 10 1106-13

    2009

    Effects of light smoking consumption on the clinical course of Crohn's disease.,

    Seksik P., Nion-Larmurier I., Sokol H., Beaugerie L., Cosnes J.,

    Inflamm Bowel Dis,

    2009, 15 5 734-41

    2009

    Epstein-Barr virus-associated lymphoproliferation awareness in hemophagocytic syndrome complicating thiopurine treatment for Crohn's disease.,

    Serrate C., Silva-Moreno M., Dartigues P., Poujol-Robert A., Sokol H., Gorin N.C., Coppo P.,,

    Inflamm Bowel Dis

    2009, 15 10 1449-51

    2009

    Single immunoglobulin infusion can reverse hemodynamic failure associated with severe Clostridium difficile colitis.

    Sokol H, Maury E, Seksik P, Cosnes J, Beaugerie L.

    Am J Gastroenterol.

    2009 Oct;104(10) 2649-50.

    2009

    Inflammatory bowel disease and lymphoproliferative disorders: the dust is starting to settle.,

    Sokol H., Beaugerie L.,

    Gut ,

    2009, 58 10 1427-36

    2009

    Plexitis as a predictive factor of early postoperative clinical recurrence in Crohn's disease.,

    Sokol H., Polin V., Lavergne-Slove A., Panis Y., Treton X., Dray X., Bouhnik Y., Valleur P., Marteau P.,

    Gut ,

    2009, 58 9 1218-25

    2009

    Low counts of Faecalibacterium prausnitzii in colitis microbiota.,

    Sokol H., Seksik P., Furet J.P., Firmesse O., Nion-Larmurier I., Beaugerie L., Cosnes J., Corthier G., Marteau P., Doré J.,

    Inflamm Bowel Dis

    2009, 15 8 1183-9

    2009

    Gastrointestinal bleeding diagnosed using video capsule endoscopy. Meckel's diverticulum.,

    Sokol H., Seksik P., Wendum D., Bellanger J., Parc Y., Cosnes J., Beaugerie L.,,

    Gut

    2009, 58 9 1206, 1290

    2009

    Thalidomide as a treatment for refractory CGD colitis.,

    Sokol H., Suarez F., Meatchi T., Malamut G., Pocidalo M.-A., Blanche S., Cellier C., Hermine O

    Am J Gastroenterol.

    2009, 104 4 1069

    2009

    Newborn hearing screening follow-up factors affecting hearing aid fitting by 6 months of age.

    Spivak L, Sokol H, Auerbach C, Gershkovich S.

    Am J Audiol.

    2009 Jun;18(1) 24-33.

    2009

    Galectin-4-regulated delivery of glycoproteins to the brush border membrane of enterocyte-like cells.

    Stechly L, Morelle W, Dessein AF, André S, Grard G, Trinel D, Dejonghe MJ, Leteurtre E, Drobecq H, Trugnan G, Gabius HJ, Huet G.

    Traffic.

    2009 Apr;10(4) 438-50.

    2009

    Azathioprine withdrawal in patients with Crohn's disease maintained on prolonged remission a high risk of relapse.

    Treton X, Bouhnik Y, Mary JY, Colombel JF, Duclos B, Soule JC, Lerebours E, Cosnes J, Lemann M; Groupe D'Etude Thérapeutique Des Affections Inflammatoires Du Tube Digestif (GETAID).

    Clin Gastroenterol Hepatol.

    2009 Jan;7(1) 80-5.

    2008

    The homeodomain derived peptide Penetratin induces curvature of fluid membrane domains.,

    Lamaziere A., Wolf, C., Lambert. O., Chassaing G., Trugnan G., Ayala-Sanmartin J.,

    PLoS ONE ,

    2008, 3 4 e1938

    2008

    [Chronic intestinal pseudo-obstruction and anti-Hu syndrome13 years of follow-up without neoplasia].

    Amiot A, Joly F, Messing B, Sokol H, Lavergne-Slove A, Delattre JY, Bouhnik Y.

    Gastroenterol Clin Biol.

    2008 Jan;32(1 Pt.

    2008

    [Antibiotic-associated diarrhea].

    Beaugerie L.

    Rev Prat.

    2008 Jun 15;58(11) 1207-12.

    2008

    [Microscopic colitis nosological face-lift and research tracks].

    Beaugerie L.

    Gastroenterol Clin Biol.

    2008, Aug-Sep;32(8-9) 686-8.

    2008

    Predictive factors of response to cyclosporine in steroid-refractory ulcerative colitis.

    Cacheux W, Seksik P, Lemann M, Marteau P, Nion-Larmurier I, Afchain P, Daniel F, Beaugerie L, Cosnes J.

    Am J Gastroenterol.

    2008 Mar;103(3) 637-42.

    2008

    Incidence of autoimmune diseases in celiac disease protective effect of the gluten-free diet.

    Cosnes J, Cellier C, Viola S, Colombel JF, Michaud L, Sarles J, Hugot JP, Ginies JL, Dabadie A, Mouterde O, Allez M, Nion-Larmurier I; Groupe D'Etude et de Recherche Sur la Maladie Coeliaque.

    Clin Gastroenterol Hepatol.

    2008 Jul;6(7) 753-8.

    2008

    Crohn's disease phenotype, prognosis, and long-term complications what to expect?

    Cosnes J.

    Acta Gastroenterol Belg.

    2008 Jul-Sep;71(3) 303-7.

    2008

    What is the link between the use of tobacco and IBD.

    Cosnes J.

    Inflamm Bowel Dis

    2008 Oct;14 Suppl 2S14-5.

    2008

    Effect of antibiotic therapy on human fecal microbiota and the relation to the development of Clostridium difficile.

    De La Cochetiere MF, Durand T, Lalande V, Petit JC, Potel G, Beaugerie L.

    Microb Ecol.

    2008 Oct;56(3) 395-402.

    2008

    Differential solubilization of inner plasma membrane leaflet components by Lubrol WX and Triton X-100.

    Delaunay JL, Breton M, Trugnan G, Maurice M.

    BBA - Biochimica et Biophysica Acta ,

    2008 Jan;1778(1) 105-12.

    2008

    Expression of nonstructural rotavirus protein NSP4 mimics Ca2+ homeostasis changes induced by rotavirus infection in cultured cells.

    Diaz Y, Chemello ME, Pena F, Aristimuno OC, Zambrano JL, Rojas H, Bartoli F, Salazar L, Chwetzoff S, Sapin C, Trugnan G, Michelangeli F, Ruiz MC.

    J Virol.

    2008 Nov;82(22) 11331-43.

    2008

    High levels of zidovudine (AZT) and its intracellular phosphate metabolites in AZT- and AZT-lamivudine-treated newborns of human immunodeficiency virus-infected mothers.

    Durand-Gasselin L, Pruvost A, Dehée A, Vaudre G, Tabone MD, Grassi J, Leverger G, Garbarg-Chenon A, Bénech H, Dollfus C.

    Antimicrob Agents Chemother.

    2008 Jul;52(7) 2555-63.

    2008

    Significance of erythema nodosum and pyoderma gangrenosum in inflammatory bowel diseases a cohort study of 2402 patients.

    Farhi D, Cosnes J, Zizi N, Chosidow O, Seksik P, Beaugerie L, Aractingi S, Khosrotehrani K.

    Medicine.

    2008 Sep;87(5) 281-93.

    2008

    MD-2 controls bacterial lipopolysaccharide hyporesponsiveness in human intestinal epithelial cells.

    Lenoir C, Sapin C, Broquet AH, Jouniaux AM, Bardin S, Gasnereau I, Thomas G, Seksik P, Trugnan G, Masliah J, Bachelet M.

    Life Sci.

    2008 Feb 27;82(9-10) 519-28.

    2008

    Rotavirus gastroenteritis why to back up the development of new vaccines?

    Parez N.

    Comp Immunol Microbiol Infect Dis.

    2008 Mar;31(2-3) 253-69.

    2008

    Risk factors associated with small bowel adenocarcinoma in Crohn's disease a case-control study.

    Piton G, Cosnes J, Monnet E, Beaugerie L, Seksik P, Savoye G, Cadiot G, Flourie B, Capelle P, Marteau P, Lemann M, Colombel JF, Khouri E, Bonaz B, Carbonnel F.

    Am J Gastroenterol.

    2008 Jul;103(7) 1730-6.

    2008

    Rearrangements of rotavirus genomic segment 11 are generated during acute infection of immunocompetent children and do not occur at random.

    Schnepf N, Deback C, Dehee A, Gault E, Parez N, Garbarg-Chenon A.

    J Virol.

    2008 Apr;82(7) 3689-96.

    2008

    [Severe attack of ulcerative colitis an observation].

    Seksik P.

    Gastroenterol Clin Biol.

    2008 Dec;32(12) 1038-40.

    2008

    Is there any place for alimentary probiotics, prebiotics or synbiotics, for patients with inflammatory bowel disease?,

    Seksik P., Dray X., Sokol H., Marteau P.,

    Molecular Nutrition and Food Research ,

    2008, 52 8 906-12

    2008

    Disease activity and cancer risk in inflammatory bowel disease associated with primary sclerosing cholangitis.,

    Sokol H., Cosnes J., Chazouilleres O., Beaugerie L., Tiret E., Poupon R., Seksik P.,,

    World J Gastroenterology

    2008, 14 22 3497-503

    2008

    Analysis of bacterial bowel communities of IBD patients: what has it revealed?,

    Sokol H., Lay C., Seksik P., Tannock G. W.,

    Inflamm Bowel Dis

    2008, 14 6 858-67

    2008

    Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients.,

    Sokol H., Pigneur B., Watterlot L., Lakhdari O., Berm˙dez-Humar·n L. G., Gratadoux J.-J., Blugeon S., Bridonneau C., Furet J.-P., Corthier G., Grangette C., Vasquez N., Pochart P., Trugnan G., Thomas G., Blottière H. M., Doré J., Marteau P., Seksik P., Langella P.,,

    Proc Natl Acad Sci U S A.

    2008, 105 43 16731-6

    2008

    Cost-effectiveness analysis of vaccination against rotavirus with RIX4414 in France.

    Standaert B, Parez N, Tehard B, Colin X, Detournay B.

    Appl Health Econ Health Policy.

    2008, 6(4) 199-216. doi 10.2165/00148365-

    200806040-00003.

    2008

    [Tolerance and efficacy of mefloquine as the first line treatment of uncomplicated P. falciparum malaria in children].

    Valeyre P, Favier R, Adam M, Quinet B, Grimprel E, Parez N.

    Pathol Biol (Paris).

    2008, Feb;56(1) 21-8.





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    Equipe:


    BACHELET Marie
    BEAUGERIE Laurent
    BERBAR Tsouria
    BROT Loic
    CHEVY Françoise
    CHWETZOFF Serge Pubmed
    COSNES Jacques  Pubmed
    GARBARG-CHENON Antoine  Pubmed
    GRILL Jean-Pierre Pubmed
    GROISARD Lucette
      HUMBERT Lydie
    LAYANI Sarah
    MASLIAH Joëlle Pubmed
    RAINTEAU DominiquePubmed
    SEKSIK PhilippePubmed
    SOKOL Harry
    THOMAS Ginette
    TRUGNAN Germain Pubmed
    WOLF Claude

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    DUBOC Henri
    DUPONCHEL Sarah

    LAMAZIERE Antonin
    MAUBERT Marie-Anne
    PIGNEUR Bénédicte
    QUEVRAIN Elodie

    SCHNURIGER Aurélie
    RAJCA Sylvie
    TROGNO-FARABO Dominique
    VU Lan Trang


     

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